Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | RAB9A | P51151 | 8/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186602 | 0.91 | FOXO1 (0.40) | IRAK4NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2187052 | 0.90 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2187178 | 0.87 | CSNK1D (0.45) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2186693 | 0.87 | MMP2 (0.46) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2186979 | 0.87 | MAPT (0.44) | NPC1RAB9ASMN1; SMN2TP53KDM4E | |
| SCHEMBL2189024 | 0.83 | CSNK1E (0.49) | NPC1SMN1; SMN2TP53PKMMTOR | |
| SCHEMBL2186995 | 0.81 | IRAK4 (0.51) | IRAK4NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL2187310 | 0.79 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL2189072 | 0.79 | CSNK1E (0.58) | NPC1RAB9ATP53PKMMTOR | |
| SCHEMBL2185628 | 0.77 | SMN1; SMN2 (0.39) | NPC1RAB9ASMN1; SMN2CSNK1EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |