Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29713454 | 1.00 | CYP11B1 (0.30) | CYP11B1CYP11B2 | |
| SCHEMBL28507565 | 0.82 | — | — | |
| SCHEMBL29713466 | 0.82 | — | — | |
| SCHEMBL21922443 | 0.82 | — | — | |
| SCHEMBL15879213 | 0.81 | — | — | |
| SCHEMBL23106729 | 0.77 | ERN1 (0.33) | — | |
| SCHEMBL7557377 | 0.73 | TRPV4 (0.39) | — | |
| SCHEMBL23106764 | 0.71 | ACHE (0.32) | — | |
| SCHEMBL21873113 | 0.70 | KDM4E (0.40) | CYP11B1CYP11B2 | |
| SCHEMBL29713462 | 0.70 | KDM4E (0.40) | CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643719-B1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-08-10 | — | — | EP | disclosed |
| US-11180509-B2 | Thiazolidone spiro pyrimidine trione compound, preparation method therefor and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-11-23 | — | — | US | disclosed |
| US-11180509-B2 | Thiazolidone spiro pyrimidine trione compound, preparation method therefor and uses thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-11-23 | — | — | US | disclosed |
| US-20210079019-A1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-03-18 | — | — | US | disclosed |
| US-20210079019-A1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-03-18 | — | — | US | disclosed |
| EP-3643719-A1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-04-29 | — | — | EP | disclosed |
| EP-3643719-A1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CN) | 2020-04-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210079019-A1 | THIAZOLIDONE SPIRO PYRIMIDINE TRIONE COMPOUND, PREPARATION METHOD THEREFOR AND USES THEREOF | DHPS, WEE1, TYMS | CYP11B1 139/4885CYP11B2 185/4885 |
| US-11180509-B2 | Thiazolidone spiro pyrimidine trione compound, preparation method therefor and uses thereof | DHPS, WEE1, TYMS | CYP11B1 139/4885CYP11B2 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.