Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 15/20 | 0.48 |
| ▸ | GPR34 | Q9UPC5 | 2/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.41 |
| ▸ | FPR2 | P25090 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2185465 | 0.79 | SCN9A (0.49) | SCN9AFPR2CNR2 | |
| SCHEMBL2187665 | 0.78 | S1PR1 (0.55) | SCN9AS1PR1 | |
| SCHEMBL2171623 | 0.78 | PTPN1 (0.57) | SCN9AGPR34CNR2 | |
| SCHEMBL1371808 | 0.75 | S1PR1 (0.73) | SCN9AS1PR1 | |
| SCHEMBL2352923 | 0.75 | SCN9A (0.64) | SCN9AGPR34 | |
| SCHEMBL2357204 | 0.75 | SCN9A (0.52) | SCN9AGPR34 | |
| SCHEMBL2353034 | 0.74 | SCN9A (0.48) | SCN9AGPR34FPR2 | |
| SCHEMBL2172340 | 0.74 | SCN9A (0.51) | SCN9AGPR34FPR2 | |
| SCHEMBL2169958 | 0.73 | SCN9A (0.47) | SCN9ACNR2 | |
| SCHEMBL2171096 | 0.72 | SCN9A (0.51) | SCN9AGPR34 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346821-A1 | SPHINGOSINE-1-PHOSPHATE RECEPTOR ANTAGONISTS | Exelixis, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |