Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL302970 | 0.81 | LMNA (0.59) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL3237944 | 0.65 | TP53 (0.74) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL10848483 | 0.65 | ALDH1A1 (0.57) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL10849362 | 0.64 | LMNA (0.51) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL21469193 | 0.64 | ALDH1A1 (0.48) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL302225 | 0.63 | LMNA (0.60) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL10850699 | 0.63 | LMNA (0.48) | LMNAMAPTPOLBALDH1A1MEN1 | |
| SCHEMBL4523697 | 0.62 | NOTUM (0.60) | MAPTALDH1A1HPGDMAPK1TP53 | |
| SCHEMBL5781435 | 0.62 | TRIM24 (0.65) | MAPTALDH1A1HPGDMAPK1TP53 | |
| SCHEMBL3376926 | 0.62 | MAPT (0.60) | LMNAMAPTALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | disclosed |