Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 3/20 | 0.32 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 4/20 | 0.32 |
| ▸ | GABRD | O14764 | 4/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4624879 | 0.82 | — | — | |
| SCHEMBL12955160 | 0.82 | — | — | |
| SCHEMBL642457 | 0.82 | — | — | |
| Water SCHEMBL21879757 | 0.78 | — | — | |
| SCHEMBL21820916 | 0.77 | SLC7A5 (0.48) | ALDH1A1MAPTPTGS1SLC7A5SLC1A3 | |
| 2,2,3-Trimethylbutane SCHEMBL2103951 | 0.72 | ALDH1A1 (0.41) | ALDH1A1MAPTPTGS1SLC7A5TSHR | |
| Bicarbonate SCHEMBL9328940 | 0.72 | SLC7A5 (0.56) | ALDH1A1MAPTPTGS1SLC7A5SLC1A3 | |
| Bicarbonate SCHEMBL28325968 | 0.72 | TSHR (0.41) | ALDH1A1MAPTPTGS1SLC7A5TSHR | |
| SCHEMBL318356 | 0.71 | SLC7A5 (0.48) | ALDH1A1MAPTPTGS1SLC7A5SLC1A3 | |
| SCHEMBL6974551 | 0.71 | SLC7A5 (0.48) | ALDH1A1MAPTPTGS1SLC7A5SLC1A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020085658-A1 | CARBON DIOXIDE ABSORBENT COMPRISING DIAMINE HYDRATE AND CARBON DIOXIDE SUPPLYING AGENT PREPARED FROM SAME | 광주과학기술원 | 2020-04-30 | — | — | WO | disclosed |