Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.33 |
| ▸ | YAP1 | P46937 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAT2A | P31153 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190316 | 0.76 | ADORA1 (0.53) | ADORA1ADORA2AADORA3LRRK2 | |
| SCHEMBL2188560 | 0.73 | ADORA1 (0.58) | ADORA1ADORA2AALDH1A1KDM4EGAA | |
| SCHEMBL30500672 | 0.70 | ALDH1A1 (0.45) | ADORA1ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL2186774 | 0.69 | ADORA2A (0.46) | ADORA1ADORA2AADORA3LRRK2MAPT | |
| SCHEMBL2187983 | 0.69 | ADORA2A (0.56) | ADORA1ADORA2ALRRK2FGFR1KDR | |
| SCHEMBL2184224 | 0.69 | ADORA2A (0.47) | ADORA1ADORA2ALRRK2FGFR1KDR | |
| SCHEMBL2185605 | 0.68 | ADORA2A (0.46) | ADORA1ADORA2ALRRK2MAPT | |
| SCHEMBL30500674 | 0.67 | ALDH1A1 (0.42) | ADORA1ALDH1A1KDM4EKMT2AGAA | |
| SCHEMBL13853257 | 0.66 | ADK (0.44) | ALDH1A1KDM4EKMT2AGAALRRK2 | |
| SCHEMBL2244688 | 0.65 | PAK4 (0.41) | ALDH1A1GAAMAPTRAB9AMAT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346859-A1 | HETEROCYCLIC JAK KINASE INHIBITORS | AstraZeneca AB (SE) | 2011-07-27 | — | — | EP | disclosed |