Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL2313359 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL9580813 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL1524832 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL1533756 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL1270294 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL445853 | 1.00 | MEN1 (0.91) | — | |
| Tromethamine SCHEMBL8135568 | 0.96 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL27944889 | 0.96 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL1417748 | 0.96 | MEN1 (0.83) | — | |
| Tromethamine SCHEMBL7193878 | 0.96 | MEN1 (0.83) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 96789 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260146355-A1 | \"Golden\" - Gold Nanomaterials | AG-NANO SYSTEM LLC (US) | 2026-05-28 | — | — | US | claimed |
| US-20260144861-A1 | COMBINATION VACCINES AGAINST CORONAVIRUS INFECTION, INFLUENZA INFECTION, AND/OR RSV INFECTION | BioNTech SE (DE) | 2026-05-28 | — | — | US | claimed |
| CN-117736704-B | Oleophobic agent for improving stability of well wall, preparation and application thereof and drilling fluid | CHINA NATIONAL PETROLEUM CORP. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122075805-A | Anticoagulation anti-infection dialysis catheter coating and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-121271994-B | Preparation method and application of alpha-2, 3 sialyltransferase-mediated sugar chain site-directed conjugated antibody drug conjugate | Wuhan Tangzhi Pharmaceutical Co.,Ltd. (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122075384-A | Cell membrane vesicle self-assembly body loaded with spirulina PDRN and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-122076062-A | Super-hydrophilic/underwater super-oleophobic copper mesh based on codeposition of polydopamine and nanocellulose and preparation method thereof | — | 2026-05-26 | — | — | CN | claimed |
| CN-119606914-B | Macrophage bionic nano composite medicine and preparation method and application thereof | SICHUAN UNIVERSITY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-121075823-B | Molybdenum oxide-molybdenum disulfide@poly tannic acid electrode material and preparation method and application thereof | ANHUI UNIVERSITY OF CHINESE MEDICINE (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-122081257-A | Enzyme preparation and method for preparing scyllo-inositol by using same | — | 2026-05-26 | — | — | CN | claimed |
| EP-0094366-A1 | Thermal energy storage system | Monsanto Company (US) | 1983-11-16 | — | — | EP | claimed |
| US-4390517-A | WATER-SOLUBLE PRIMARY, SECONDARY, OR TERTIARY AMINES AS STABILIZERS; DIAGNOSIS/MEDICAL/; STORAGE STABILITY | NEW ENGLAND NUCLEAR CORPORATION (US) | 1983-06-28 | — | — | US | claimed |
| EP-0072147-A1 | Fresh water fish environment | AQUARIUM PHARMACEUTICALS INC. (US) | 1983-02-16 | — | — | EP | claimed |
| US-4307082-A | Method for the extraction of a factor that mediates contact inhibition of cell growth | NEW YORK UNIVERSITY (US) | 1981-12-22 | — | — | US | claimed |
| US-4265881-A | ANTITHROMBOTIC AGENT BY FRACTIONATION FROM BILE | TOBISHI PHARMACEUTICAL CO., LTD. (JP) | 1981-05-05 | — | — | US | claimed |
| WO-1981001101-A1 | IMPROVEMENTS IN OR RELATING TO VACCINES | LEHNER T | 1981-04-30 | — | — | WO | claimed |
| US-4059490-A | Measurement of alkaline phosphatase levels in body fluids | CHEMBRO HOLDINGS (PROPRIETARY) LIMITED (ZA) | 1977-11-22 | — | — | US | claimed |
| US-4020162-A | Oxytetracycline solution for parenteral, peroral and local administration and processes for the production thereof | CIBA-GEIGY CORPORATION (US) | 1977-04-26 | — | — | US | claimed |
| US-3973002-A | Antihemophilic factor | E. R. SQUIBB & SONS, INC. (US) | 1976-08-03 | — | — | US | claimed |
| US-3931399-A | MULTISTAGE FROM EXTRACTION OF HUMAN PLACENTAE | BEHRINGWERKE AKTIENGESELLSCHAFT (DT) | 1976-01-06 | — | — | US | claimed |