Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.91 |
| ▸ | LMNA | P02545 | 1/20 | 0.91 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.91 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromethamine SCHEMBL2188 | 1.00 | — | — | |
| Tromethamine SCHEMBL2313359 | 1.00 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1524832 | 1.00 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1533756 | 1.00 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1270294 | 1.00 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL445853 | 1.00 | MEN1 (0.91) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL8135568 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL27944889 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL1417748 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E | |
| Tromethamine SCHEMBL7193878 | 0.96 | MEN1 (0.83) | MEN1LMNAKMT2AS1PR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119876118-A | Reagent for extracting RNA in mature corn grains and embryo with high quality and application method thereof | 中国科学院遗传与发育生物学研究所 | 2025-04-25 | — | — | CN | claimed |
| CN-118159652-A | Precipitant composition for DNA extraction and DNA extraction method using same | 韩国尖端试验研究院 | 2024-06-07 | — | — | CN | claimed |
| CN-114480615-B | Primer group and kit for detecting HLA-B5101 alleles | 泰兴市人民医院 | 2024-03-22 | — | — | CN | claimed |
| CN-114773526-A | Degradable photoresist and application thereof in 3D printing | 东南大学 | 2022-07-22 | — | — | CN | claimed |
| CN-103808906-B | A kind of tobacco juice for electronic smoke Cytotoxic evaluation method based on determination of lactate dehydrogenase | NATIONAL TOBACCO QUALITY SUPERVISION TESTING CENTER (CN) | 2015-08-12 | — | — | CN | claimed |
| CN-103820524-A | Lactic dehydrogenase determination-based cigarette smoke cell toxicity evaluation method | NAT TOBACCO QUALITY SUPERVISION & INSPECTION CT | 2014-05-28 | — | — | CN | claimed |
| CN-103808906-A | Electronic cigarette smoke solution cell toxicity evaluation method based on lactate dehydrogenase (LDH) assaying | NAT TOBACCO QUALITY SUPERVISION & INSPECTION CT | 2014-05-21 | — | — | CN | claimed |
| CN-1237050-C | Synthesis of 2,6-diaminemethylpyridine derivative fluoescence chemical sensor molecule and its application | UNIV DALIAN TECH (CN) | 2006-01-18 | — | — | CN | claimed |
| CN-122006808-A | Method for preparing dopamine-coated titanium dioxide photocatalyst based on hydrothermal method | 中汽研汽车检验中心（天津）有限公司 | 2026-05-12 | — | — | CN | disclosed |
| CN-121869314-A | Preparation method and application of industrial arsenic-removing nano metal adsorbent | 中国石油天然气股份有限公司 | 2026-04-17 | — | — | CN | disclosed |
| CN-119876405-A | Multiplex PCR primer probe combination and kit for human erythrocyte RHD genotyping detection | 江苏伟禾生物科技有限公司 | 2025-04-25 | — | — | CN | disclosed |
| CN-119700677-A | DNA nano-particle and preparation method thereof | 天津大学浙江研究院 | 2025-03-28 | — | — | CN | disclosed |
| CN-119592710-A | Multiplex PCR primer probe combination, kit and detection method for human erythrocyte RHCE genotyping detection | 江苏伟禾生物科技有限公司 | 2025-03-11 | — | — | CN | disclosed |
| CN-118949124-A | Manufacturing method of microporous titanium metatarsal implant | 自贡市第四人民医院(自贡市急救中心) | 2024-11-15 | — | — | CN | disclosed |
| WO-2016098028-A1 | END CAPPED NUCLEIC ACID MOLECULES | NOVARTIS AG (CH) | 2016-06-23 | — | — | WO | disclosed |
| CN-103808906-B | A kind of tobacco juice for electronic smoke Cytotoxic evaluation method based on determination of lactate dehydrogenase | NATIONAL TOBACCO QUALITY SUPERVISION TESTING CENTER (CN) | 2015-08-12 | — | — | CN | disclosed |
| CN-103820524-A | Lactic dehydrogenase determination-based cigarette smoke cell toxicity evaluation method | NAT TOBACCO QUALITY SUPERVISION & INSPECTION CT | 2014-05-28 | — | — | CN | disclosed |
| CN-103808906-A | Electronic cigarette smoke solution cell toxicity evaluation method based on lactate dehydrogenase (LDH) assaying | NAT TOBACCO QUALITY SUPERVISION & INSPECTION CT | 2014-05-21 | — | — | CN | disclosed |
| US-5223554-A | Comprising anions of cyanate, formate, hypophosphite, nitrate, phosphite and sulfamate; used with magnesium hardening agent | BORDEN, INC. (US) | 1993-06-29 | — | — | US | disclosed |
| US-4703036-A | ANTICOAGULANTS | RICHTER GEDEON VEGYESZETI GYAR RT (HU) | 1987-10-27 | — | — | US | disclosed |