Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 9/20 | 0.60 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.60 |
| ▸ | ACE | P12821 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.40 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7650354 | 0.86 | ESR1 (0.44) | ESR1ESR2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL21959086 | 0.82 | MEN1 (0.54) | MEN1CYP1A2CYP2C19KMT2A | |
| SCHEMBL8986819 | 0.79 | ESR1 (0.54) | ESR1ESR2ACE | |
| SCHEMBL8986825 | 0.79 | ESR1 (0.54) | ESR1ESR2ACE | |
| SCHEMBL11459400 | 0.78 | ACE (0.63) | ESR1ESR2ACESLC7A5 | |
| SCHEMBL11459401 | 0.78 | ACE (0.63) | ESR1ESR2ACESLC7A5 | |
| SCHEMBL5328241 | 0.76 | SMN1; SMN2 (0.49) | ESR1ESR2SMN1; SMN2ALDH1A1HTT | |
| SCHEMBL28582286 | 0.75 | MDM4 (0.58) | ESR1ESR2ACEALDH1A1KMT2A | |
| SCHEMBL28582287 | 0.75 | MDM4 (0.58) | ESR1ESR2ACEALDH1A1KMT2A | |
| SCHEMBL10058428 | 0.75 | ALDH1A1 (0.43) | ESR1ESR2ALDH1A1HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11453632-B2 | 1-phenyl-2-phenylethane derivative | KAO CORPORATION (JP) | 2022-09-27 | — | — | US | disclosed |
| CN-112912363-B | 1-phenyl-2-phenylethane derivatives | 花王株式会社 | 2022-06-03 | — | — | CN | disclosed |
| US-20220009869-A1 | 1-PHENYL-2-PHENYLETHANE DERIVATIVE | KAO CORPORATION (JP) | 2022-01-13 | — | — | US | disclosed |
| CN-112912363-A | 1-phenyl-2-phenylethane derivatives | 花王株式会社 | 2021-06-04 | — | — | CN | disclosed |
| WO-2020085373-A1 | 1-PHENYL-2-PHENYLETHANE DERIVATIVE | 花王株式会社 | 2020-04-30 | — | — | WO | disclosed |
| WO-2020085373-A1 | 1-PHENYL-2-PHENYLETHANE DERIVATIVE | 花王株式会社 | 2020-04-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220009869-A1 | 1-PHENYL-2-PHENYLETHANE DERIVATIVE | ESR2, GPER1, ESR1 | ESR1 3/4885ESR2 1/4885ACE 2944/4885 |
| US-11453632-B2 | 1-phenyl-2-phenylethane derivative | ESR2, GPER1, ESR1 | ESR1 3/4885ESR2 1/4885ACE 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.