SCHEMBL2188108

SCHEMBL2188108

O=C1OC(=O)c2cc(ccc2C(=O)O)-c2cccc1c2

nearest known ligand 0.49

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
TYMS P04818 1/20 0.49
ACMSD Q8TDX5 5/20 0.47
HNF4A P41235 3/20 0.46
XDH P47989 1/20 0.44
SLC22A12 Q96S37 1/20 0.44
MCL1 Q07820 2/20 0.42
DHFR P00374 1/20 0.42
DCLRE1B Q9H816 3/20 0.41
DCLRE1A Q6PJP8 1/20 0.41
KMO O15229 1/20 0.41
PTPN1 P18031 2/20 0.40
KDM4E B2RXH2 1/20 0.38
GFER P55789 1/20 0.38
KMT2A Q03164 1/20 0.38
RXFP1 Q9HBX9 1/20 0.38
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA4 P22748 1/20 0.38
CA7 P43166 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL538529 0.93 TYMS (0.50) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL168301 0.91 TYMS (0.51) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL1245664 0.84 TYMS (0.50) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL11863723 0.83 TYMS (0.45) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL4355709 0.81 TYMS (0.46) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL11867738 0.80 TYMS (0.43) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL14321815 0.80 TYMS (0.49) TYMSACMSDHNF4AMCL1KDM4E
SCHEMBL475841 0.79 TYMS (0.42) TYMSACMSDHNF4AXDHSLC22A12
SCHEMBL1142632 0.78 TYMS (0.50) TYMSACMSDHNF4AXDHSLC22A12
Pyromellitic Acid SCHEMBL10568706 0.77 CA12 (0.50) TYMSACMSDHNF4AMCL1DHFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8449200-B2 Resin composition for sliding member and rolling bearing NTN CORPORATION (JP) 2013-05-28 US disclosed
US-8182155-B2 Lubricating grease and lubricating grease-enclosed roller bearing NTN CORPORATION (JP) 2012-05-22 US disclosed
US-7973122-B2 Polyamideimide compositions having multifunctional core structures GENERAL CABLE TECHNOLOGIES CORPORATION (US) 2011-07-05 US disclosed
US-20100142872-A1 RESIN COMPOSITION FOR SLIDING MEMBER AND ROLLING BEARING NTN CORPORATION (JP) 2010-06-10 US disclosed
EP-2157135-A1 RESIN COMPOSITION FOR SLIDE MEMBER AND ROLLER BEARING NTN Corporation (JP) 2010-02-24 EP disclosed
US-20090232432-A1 Lubricating grease and lubricating grease-enclosed roller bearing NTN CORPORATION (JP) 2009-09-17 US disclosed
EP-1956072-A1 LUBRICATING GREASE AND LUBRICATING-GREASE-FILLED ROLLER BEARING NTN CORPORATION (JP) 2008-08-13 EP disclosed
US-20080160304-A1 Polyamideimide compositions having multifunctional core structures GENERAL CABLE TECHNOLOGIES 2008-07-03 US disclosed
US-20050282010-A1 Polyamideimide compositions having multifunctional core structures GENERAL CABLE TECHNOLOGIES CORPORATION 2005-12-22 US disclosed
US-5840802-A HEAT RESISTANCE AND IMPACT STRENGTH FOR THERMOPLASTIC RESINS GENERAL ELECTRIC COMPANY (US) 1998-11-24 US disclosed
US-5306785-A Molding materials GENERAL ELECTRIC COMPANY (US) 1994-04-26 US disclosed
EP-0586181-A2 Thermoplastic polyester elastomer resin compositions GE PLASTICS JAPAN LIMITED (JP) 1994-03-09 EP disclosed
EP-0322778-B1 BICOMPONENT MOISTURE BARRIER POLY(ETHERIMIDE) ESTER FILMS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1993-09-08 EP disclosed
EP-0537014-A2 Dual graft stage and thermally stabilized polyorganisiloxane/polyvinyl-based graft copolymers and thermoplastic compositions containing the same GENERAL ELECTRIC COMPANY (US) 1993-04-14 EP disclosed
EP-0322777-B1 VAPOR PERMEABLE POLY(ETHERIMIDE) ESTER ELASTOMER FILMS E.I. DU PONT DE NEMOURS AND COMPANY (US) 1992-11-04 EP disclosed
EP-0322777-A1 Vapor permeable poly(etherimide) ester elastomer films E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-05 EP disclosed
EP-0322778-A2 Bicomponent moisture barrier poly(etherimide) ester films E.I. DU PONT DE NEMOURS AND COMPANY (US) 1989-07-05 EP disclosed
US-4769273-A HAVING DIFFERENTIAL TRANSFER OF WATER VAPOR TO PREVENT BUILD-UP; TEXTILE COVERING; SURGICAL DRAPES; WATERPROOFED CLOTHING E. I. DU PONT DE NEMOURS AND COMPANY (US) 1988-09-06 US disclosed