Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24133235 | 0.84 | SMN1; SMN2 (0.35) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL18791344 | 0.81 | KMT2A (0.40) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL1637655 | 0.79 | MAPT (0.38) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL21882016 | 0.78 | SMN1; SMN2 (0.59) | MAPTALDH1A1SMN1; SMN2NPC1PKM | |
| SCHEMBL1638626 | 0.78 | AXL (0.53) | MAPTALDH1A1SMN1; SMN2NPC1PKM | |
| SCHEMBL9885167 | 0.77 | RAB9A (0.44) | MAPTALDH1A1SMN1; SMN2NPC1PKM | |
| SCHEMBL24225514 | 0.74 | NPC1 (0.65) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL10218875 | 0.73 | KMT2A (0.40) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL2733560 | 0.70 | MAPT (0.37) | MAPTAKR1B1ALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL7700068 | 0.69 | GFER (0.61) | MAPTALDH1A1SMN1; SMN2NPC1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2023-02-16 | — | — | US | disclosed |
| US-11318133-B2 | Modulators of integrated stress response pathway | Praxis Biotech LLC (US) | 2022-05-03 | — | — | US | disclosed |
| US-11230542-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2022-01-25 | — | — | US | disclosed |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ALTOS LABS, INC. | 2021-10-14 | — | — | US | disclosed |
| US-20200390759-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-12-17 | — | — | US | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317102-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | MAPT 4258/4885AKR1B1 2292/4885ALDH1A1 4073/4885 |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | MAPT 4258/4885AKR1B1 2292/4885ALDH1A1 4073/4885 |
| US-11230542-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | MAPT 4258/4885AKR1B1 2292/4885ALDH1A1 4073/4885 |
| US-20200390759-A1 | MODULATORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, ATF1, DDIT3 | MAPT 4481/4885AKR1B1 2320/4885ALDH1A1 4237/4885 |
| US-11318133-B2 | Modulators of integrated stress response pathway | ATF4, ATF1, DDIT3 | MAPT 4481/4885AKR1B1 2320/4885ALDH1A1 4237/4885 |
| US-20230047589-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | MAPT 4258/4885AKR1B1 2292/4885ALDH1A1 4073/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | MAPT 4258/4885AKR1B1 2292/4885ALDH1A1 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.