Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ILK | Q13418 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18791159 | 0.84 | MMP1 (0.38) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL3091345 | 0.84 | ILK (0.38) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18791344 | 0.82 | KMT2A (0.40) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1638626 | 0.79 | AXL (0.53) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL21882016 | 0.79 | SMN1; SMN2 (0.59) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL21882018 | 0.79 | MAPT (0.37) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL18315218 | 0.76 | RAB9A (0.46) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL17839736 | 0.76 | ILK (0.49) | MAPTSMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL24225514 | 0.75 | NPC1 (0.65) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL10218875 | 0.74 | KMT2A (0.40) | MAPTAKR1B1SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110098292-A1 | New Compounds Useful for Treating CNS Disorders | ASTRAZENECA AB (SE) | 2011-04-28 | — | — | US | disclosed |
| CN-1980922-A | New compounds useful for treating CNS disorders | ASTRAZENECA AB (SE) | 2007-06-13 | — | — | CN | disclosed |
| EP-1765815-A2 | NEW COMPOUNDS USEFUL FOR TREATING CNS DISORDERS | AstraZeneca AB (SE) | 2007-03-28 | — | — | EP | disclosed |
| WO-2006004507-A2 | NEW BENZOTHIAZOLE DERIVATIVES USEFUL FOR TREATING CNS DISORDERS | ASTRAZENECA AB (SE) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110098292-A1 | New Compounds Useful for Treating CNS Disorders | SLC18A2, PMP22, GAP43 | MAPT 96/4885AKR1B1 1246/4885SMN1; SMN2 138/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.