Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 3/20 | 0.57 |
| ▸ | SLC6A5 | Q9Y345 | 7/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MDH1 | P40925 | 1/20 | 0.43 |
| ▸ | MDH2 | P40926 | 1/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21819383 | 0.88 | ATF4 (0.72) | ATF4SLC6A5ALDH1A1MAPTLMNA | |
| SCHEMBL21882045 | 0.88 | ATF4 (0.76) | ATF4ALDH1A1KCNA3 | |
| SCHEMBL21819450 | 0.86 | ATF4 (0.63) | ATF4SLC6A5ALDH1A1MAPTSCN1A | |
| SCHEMBL21882036 | 0.82 | ATF4 (0.78) | ATF4 | |
| SCHEMBL28593095 | 0.78 | ATF4 (0.57) | ATF4ALDH1A1MAPTLMNAHTT | |
| SCHEMBL17583109 | 0.77 | KCNA3 (0.53) | SLC6A5KCNA3SCN9AGAA | |
| SCHEMBL5219262 | 0.77 | CKS1B (0.49) | KCNA3GAA | |
| SCHEMBL28577658 | 0.77 | ALDH1A1 (0.53) | ATF4SLC6A5ALDH1A1MAPTMDH1 | |
| Trifluoroacetic Acid SCHEMBL21819296 | 0.77 | ALDH1A1 (0.53) | ATF4SLC6A5ALDH1A1MAPTMDH1 | |
| SCHEMBL22719510 | 0.76 | TEAD1 (0.65) | SLC6A5KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2022-03-10 | — | — | US | disclosed |
| US-11166942-B2 | Inhibitors of integrated stress response pathway | Praxis Biotech LLC (US) | 2021-11-09 | — | — | US | disclosed |
| CN-112912082-A | Integrated stress pathway inhibitors | 普拉西斯生物技术有限责任公司 | 2021-06-04 | — | — | CN | disclosed |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | Praxis Biotech LLC | 2020-04-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11166942-B2 | Inhibitors of integrated stress response pathway | ATF4, DDIT3, ATF1 | ATF4 1/4885SLC6A5 2017/4885ALDH1A1 4073/4885 |
| US-20220071966-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885SLC6A5 2017/4885ALDH1A1 4073/4885 |
| US-20200101047-A1 | INHIBITORS OF INTEGRATED STRESS RESPONSE PATHWAY | ATF4, DDIT3, ATF1 | ATF4 1/4885SLC6A5 2017/4885ALDH1A1 4073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.