Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 7/20 | 0.34 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 2/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21882349 | 0.89 | TGFBR1 (0.38) | CSF1RTGFBR1SCN5ASCN9APDGFRB | |
| SCHEMBL21425572 | 0.84 | CSF1R (0.35) | CSF1RFLT3TGFBR1SCN5ASCN9A | |
| SCHEMBL21882287 | 0.84 | TGFBR1 (0.33) | CSF1RTGFBR1PDGFRBPDGFRA | |
| SCHEMBL21882296 | 0.84 | CSF1R (0.34) | CSF1RFLT3TGFBR1AXLPDGFRB | |
| SCHEMBL27116638 | 0.83 | NCF1 (0.32) | — | |
| SCHEMBL21425562 | 0.82 | RAF1 (0.39) | CSF1RSCN9APDGFRBPDGFRARAF1 | |
| SCHEMBL21882307 | 0.82 | CSF1R (0.32) | CSF1RTGFBR1SCN5ASCN9APDGFRB | |
| SCHEMBL21882348 | 0.81 | TGFBR1 (0.31) | TGFBR1SCN5ASCN9A | |
| SCHEMBL27116658 | 0.79 | TGFBR1 (0.33) | CSF1RTGFBR1SCN5ASCN9APDGFRB | |
| SCHEMBL21882309 | 0.79 | CSF1R (0.36) | CSF1RTGFBR1SCN9APDGFRBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3632907-A1 | N-(AZAARYL)CYCLOLACTAM-1-CARBOXAMIDE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2020-04-08 | — | — | EP | disclosed |