Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT6A | Q92794 | 3/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.54 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.54 |
| ▸ | FLT1 | P17948 | 2/20 | 0.53 |
| ▸ | FLT4 | P35916 | 2/20 | 0.53 |
| ▸ | KDR | P35968 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20119239 | 0.86 | KAT6A (0.57) | KAT6AHTTPSMB8PSMB5FLT1 | |
| SCHEMBL9179605 | 0.84 | PTGS2 (0.64) | KAT6APTGS2EGFRPTGS1FLT1 | |
| SCHEMBL10769381 | 0.82 | PTGS2 (0.65) | PTGS2EGFRPTGS1FLT1FLT4 | |
| SCHEMBL6641114 | 0.81 | KMT2A (0.60) | KAT6APTGS2EGFRPTGS1FLT1 | |
| SCHEMBL13209252 | 0.80 | KAT6A (0.58) | KAT6AHTTGAAKMT2ALMNA | |
| SCHEMBL5931087 | 0.79 | PTGS2 (0.71) | PTGS2EGFRPTGS1HTTFLT1 | |
| SCHEMBL23447722 | 0.78 | FFAR1 (0.61) | KAT6APTGS2EGFRPTGS1HTT | |
| SCHEMBL3292237 | 0.78 | PTGS2 (0.69) | PTGS2EGFRPTGS1HTTFLT1 | |
| SCHEMBL9176194 | 0.78 | KAT6A (0.64) | KAT6APTGS2EGFRPTGS1POLB | |
| SCHEMBL9176266 | 0.77 | PTGS2 (0.78) | PTGS2EGFRPTGS1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | KAT6A 2864/4885PTGS2 1196/4885EGFR 1735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.