Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.44 |
| ▸ | OGA | O60502 | 2/20 | 0.43 |
| ▸ | HPGDS | O60760 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | F2 | P00734 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MGAM | O43451 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20173757 | 0.89 | ALOX15 (0.50) | ALOX15HTTPSMD14OGAHPGDS | |
| SCHEMBL10466162 | 0.82 | HTT (0.67) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL18370004 | 0.81 | HTT (0.57) | ALOX15HTTHPGDSMAPK1KDM4E | |
| SCHEMBL20178580 | 0.80 | ALOX15 (0.52) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL20118976 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL1353856 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL31250404 | 0.79 | ALOX15 (0.54) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL12184392 | 0.77 | ALOX15 (0.52) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL15517731 | 0.77 | HTT (0.52) | ALOX15HTTPSMD14HPGDSMAPK1 | |
| SCHEMBL20799517 | 0.77 | ALDH1A1 (0.62) | ALOX15HTTHPGDSALDH1A1F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | ENANTA PHARMACEUTICALS, INC. (US) | 2020-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10597391-B2 | Urea-containing isoxazole derivatives as FXR agonists and methods of use thereof | NR1H4, FXR1, SLC10A1 | ALOX15 1041/4885HTT 3363/4885PSMD14 3755/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.