Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 4/20 | 0.51 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.51 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | PI4KA | P42356 | 1/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | AMD1 | P17707 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | P2RX2 | Q9UBL9 | 1/20 | 0.38 |
| ▸ | RNASEL | Q05823 | 3/20 | 0.37 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.37 |
| ▸ | NT5E | P21589 | 1/20 | 0.36 |
| ▸ | DNPH1 | O43598 | 2/20 | 0.36 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.36 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30394247 | 1.00 | P2RX3 (0.51) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL20524225 | 0.89 | P2RX3 (0.55) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL21882958 | 0.87 | P2RX3 (0.54) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL23915001 | 0.87 | P2RX3 (0.54) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL30394191 | 0.87 | P2RX3 (0.54) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL21882985 | 0.83 | DNPH1 (0.53) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL23915313 | 0.83 | DNPH1 (0.53) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL23915675 | 0.82 | NT5E (0.52) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL21882959 | 0.82 | NT5E (0.52) | P2RX3P2RX1P2RX4RXFP1PI4KA | |
| SCHEMBL30395399 | 0.82 | NT5E (0.52) | P2RX3P2RX1P2RX4RXFP1PI4KA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11591355-B2 | CD73 inhibitors and uses thereof | PELOTON THERAPEUTICS INC. (US) | 2023-02-28 | — | — | US | disclosed |
| US-20210317150-A1 | CD73 INHIBITORS AND USES THEREOF | PELOTON THERAPEUTICS, INC. (US) | 2021-10-14 | — | — | US | disclosed |
| US-20200115404-A1 | CD73 INHIBITORS AND USES THEREOF | PELOTON THERAPEUTICS INC. | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115404-A1 | CD73 INHIBITORS AND USES THEREOF | ENTPD5, ENTPD1, NT5E | P2RX3 37/4885P2RX1 39/4885P2RX4 72/4885 |
| US-11591355-B2 | CD73 inhibitors and uses thereof | ENTPD5, ENTPD1, ENTPD3 | P2RX3 14/4885P2RX1 20/4885P2RX4 33/4885 |
| US-20210317150-A1 | CD73 INHIBITORS AND USES THEREOF | ENTPD5, ENTPD1, NT5E | P2RX3 37/4885P2RX1 39/4885P2RX4 72/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.