SCHEMBL21883952

SCHEMBL21883952

CC(C)C(=O)c1ccccc1C(=O)NCCN1CCCC1

nearest known ligand 0.52

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 1/20 0.52
RAB9A P51151 1/20 0.51
ALDH1A1 P00352 1/20 0.50
MEN1 O00255 1/20 0.50
POLB P06746 1/20 0.50
KMT2A Q03164 1/20 0.50
POLR1A O95602 2/20 0.49
APP P05067 1/20 0.49
DRD2 P14416 1/20 0.49
DRD4 P21917 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21883951 0.99 MEN1 (0.52) NPSR1RAB9AALDH1A1MEN1POLB
SCHEMBL21883927 0.88 KDM4E (0.55) ALDH1A1MEN1POLBKMT2ADRD2
SCHEMBL24062684 0.88 KMT2A (0.62) ALDH1A1MEN1KMT2A
SCHEMBL24506197 0.88 NPSR1 (0.49) NPSR1RAB9AALDH1A1MEN1POLB
SCHEMBL2740260 0.85 MEN1 (0.53) NPSR1RAB9AALDH1A1MEN1POLB
SCHEMBL24333908 0.85 NPSR1 (0.56) NPSR1ALDH1A1MEN1POLBKMT2A
SCHEMBL19132941 0.84 ALDH1A1 (0.52) ALDH1A1MEN1POLBKMT2ADRD2
SCHEMBL21347710 0.83 POLB (0.55) NPSR1ALDH1A1MEN1POLBKMT2A
SCHEMBL12333392 0.83 POLB (0.62) NPSR1ALDH1A1MEN1POLBKMT2A
SCHEMBL11484492 0.83 MEN1 (0.57) NPSR1RAB9AALDH1A1MEN1POLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230381323-A1 RELEASABLE CONJUGATES FISH & RICHARDSON PC 2023-11-30 US disclosed
US-11786599-B2 Releasable conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2023-10-17 US disclosed
EP-4011396-A1 RELEASABLE CONJUGATES QuiaPEG Pharmaceuticals AB (SE) 2022-06-15 EP disclosed
US-11357828-B2 Releasable GLP-1 conjugates QUIAPEG PHARMACEUTICALS AB (SE) 2022-06-14 US disclosed
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES FISH & RICHARDSON PC 2022-04-21 US disclosed
EP-3592393-B1 RELEASABLE CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2021-12-01 EP disclosed
WO-2020053815-A1 RELEASABLE GLP-1 CONJUGATES QUIAPEG PHARMACEUTICALS AB (SE) 2020-03-19 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230381323-A1 RELEASABLE CONJUGATES GUSB, ABCB11, UGT2B7 NPSR1 430/4885RAB9A 146/4885ALDH1A1 72/4885
US-11357828-B2 Releasable GLP-1 conjugates GLP1R, GIPR, IAPP NPSR1 154/4885RAB9A 165/4885ALDH1A1 681/4885
US-11786599-B2 Releasable conjugates GUSB, ABCB11, UGT2B7 NPSR1 430/4885RAB9A 146/4885ALDH1A1 72/4885
US-20220118055-A1 RELEASABLE GLP-1 CONJUGATES GLP1R, GIPR, IAPP NPSR1 154/4885RAB9A 165/4885ALDH1A1 681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.