Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 9/20 | 0.54 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.54 |
| ▸ | BCHE | P06276 | 7/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3324386 | 1.00 | BACE1 (0.54) | BACE1SLC6A11BCHE | |
| SCHEMBL2843607 | 1.00 | BACE1 (0.54) | BACE1SLC6A11BCHE | |
| SCHEMBL2843604 | 1.00 | BACE1 (0.54) | BACE1SLC6A11BCHE | |
| SCHEMBL7305633 | 0.93 | BACE1 (0.60) | BACE1SLC6A11BCHE | |
| SCHEMBL7306846 | 0.93 | BACE1 (0.60) | BACE1SLC6A11BCHE | |
| SCHEMBL3352792 | 0.91 | BACE1 (0.54) | BACE1SLC6A11BCHE | |
| SCHEMBL3352784 | 0.91 | BACE1 (0.54) | BACE1SLC6A11BCHE | |
| SCHEMBL4349878 | 0.89 | FOLH1 (0.45) | BACE1SLC6A11BCHE | |
| SCHEMBL6051163 | 0.89 | FOLH1 (0.45) | BACE1SLC6A11BCHE | |
| SCHEMBL13537983 | 0.89 | BACE1 (0.52) | BACE1SLC6A11BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018015929-A1 | A NOVEL PROCESS FOR THE PREPARATION OF HIV PROTEASE INHIBITOR AND INTERMEDIATES THEREOF | GRANULES INDIA LIMITED (IN) | 2018-01-25 | — | — | WO | disclosed |
| EP-2235008-B1 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | JANSSEN SCIENCES IRELAND UC (IE) | 2016-03-16 | — | — | EP | disclosed |
| US-8653141-B2 | HIV protease inhibiting compounds | ABBVIE INC. (US) | 2014-02-18 | — | — | US | disclosed |
| EP-2264032-B1 | HIV PROTEASE INHIBITING SULFONAMIDES | ABBVIE INC (US) | 2013-08-07 | — | — | EP | disclosed |
| US-20130023463-A1 | HIV PROTEASE INHIBITING COMPOUNDS | ABBOTT LABORATORIES (US) | 2013-01-24 | — | — | US | disclosed |
| US-8350048-B2 | Amide compounds as boosters of antivirals | JANSSEN R&D IRELAND (IE) | 2013-01-08 | — | — | US | disclosed |
| EP-2216334-B1 | HIV protease inhibiting sulfonamides | ABBOTT LAB (US) | 2012-10-31 | — | — | EP | disclosed |
| EP-1463502-B1 | BROADSPECTRUM HETEROCYCLIC SUBSTITUTED PHENYL CONTAINING SULFONAMIDE HIV PROTEASE INHIBITORS | TIBOTEC PHARM LTD (IE) | 2011-07-13 | — | — | EP | disclosed |
| EP-2264032-A2 | Hiv protease inhibiting sulfonamides | Abbott Laboratories (US) | 2010-12-22 | — | — | EP | disclosed |
| US-20100305073-A1 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | TIBOTEC BVBA | 2010-12-02 | — | — | US | disclosed |
| EP-2235008-A2 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | Tibotec Pharmaceuticals (IE) | 2010-10-06 | — | — | EP | disclosed |
| EP-2216334-A1 | Hiv protease inhibiting sulfonamides | Abbott Laboratories (US) | 2010-08-11 | — | — | EP | disclosed |
| US-7763641-B2 | Broadspectrum heterocyclic substituted phenyl containing sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2010-07-27 | — | — | US | disclosed |
| US-7659404-B2 | Broad spectrum 2-(substituted-amino)-benzothiazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2010-02-09 | — | — | US | disclosed |
| EP-1709037-B1 | HIV PROTEASE INHIBITING SULFONAMIDES | ABBOTT LAB (US) | 2009-12-23 | — | — | EP | disclosed |
| WO-2009071650-A2 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2009-06-11 | — | — | WO | disclosed |
| EP-1370543-B1 | BROADSPECTRUM 2-(SUBSTITUTED-AMINO)-BENZOTHIAZOLE SULFONAMIDE HIV PROTEASE INHIBITORS | TIBOTEC PHARM LTD (IE) | 2006-10-25 | — | — | EP | disclosed |
| US-20050222215-A1 | Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2005-10-06 | — | — | US | disclosed |
| US-20040116485-A1 | Broad spectrum 2-(substituted-amino)-benzothiazole sulfonamide hiv protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2004-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222215-A1 | Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors | CYP2S1, PRSS1, AHCYL1 | BACE1 271/4885SLC6A11 3623/4885BCHE 1216/4885 |
| US-20130023463-A1 | HIV PROTEASE INHIBITING COMPOUNDS | SERPINB1, HPN, DNPEP | BACE1 112/4885SLC6A11 3735/4885BCHE 201/4885 |
| US-20100305073-A1 | AMIDE COMPOUNDS AS BOOSTERS OF ANTIVIRALS | CYP3A5, CYP3A4, CYP3A43 | BACE1 823/4885SLC6A11 2155/4885BCHE 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.