Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.41 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | CHUK | O15111 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 2/20 | 0.34 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884416 | 0.83 | PDPK1 (0.42) | PDPK1AAK1DYRK1AJAK2FLT3 | |
| SCHEMBL7231775 | 0.66 | CAMK2D (0.54) | PDPK1DYRK1AGAA | |
| SCHEMBL14253975 | 0.64 | CAMK2D (0.57) | JAK2FLT3PIK3CA | |
| SCHEMBL14253992 | 0.62 | SYK (0.54) | JAK2FLT3PIK3CA | |
| SCHEMBL21884787 | 0.62 | MAP2K3 (0.49) | CHUKMAPTROCK2 | |
| SCHEMBL10917245 | 0.62 | DYRK1A (0.50) | PDPK1AAK1DYRK1ACLK1 | |
| SCHEMBL14253974 | 0.61 | MAPK8 (0.61) | JAK2PIK3CA | |
| SCHEMBL28886710 | 0.61 | AURKA (0.55) | PDPK1DYRK1ACLK1 | |
| SCHEMBL10918699 | 0.61 | DYRK1A (0.53) | PDPK1DYRK1ACLK1MAPT | |
| SCHEMBL14253998 | 0.61 | MTOR (0.52) | JAK2FLT3PIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |