Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K3 | P46734 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.47 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.47 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.47 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.38 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 9/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 7/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21884393 | 0.79 | MAP2K3 (0.51) | MAP2K3MAPK14FTOEGLN1KDM5B | |
| SCHEMBL11907713 | 0.66 | MAP2K3 (0.76) | MAP2K3MAPK14PRKDCATRKDM6B | |
| SCHEMBL25376032 | 0.64 | HPGD (0.47) | MAP2K3MAPK14FTOEGLN1KDM5B | |
| SCHEMBL29106081 | 0.63 | FTO (0.62) | MAP2K3FTOEGLN1KDM5BKDM2A | |
| SCHEMBL21884786 | 0.62 | PDPK1 (0.43) | MAPTROCK2CHUK | |
| SCHEMBL10112345 | 0.62 | RAB9A (0.49) | MAP2K3MAPK14CDC7MAPTTDP1 | |
| SCHEMBL7844018 | 0.61 | FTO (0.58) | MAP2K3FTOEGLN1KDM5BKDM2A | |
| SCHEMBL3462574 | 0.60 | ATR (0.68) | PRKDCATR | |
| SCHEMBL29106060 | 0.60 | P2RY14 (0.46) | FTOEGLN1KDM5BKDM2AMAPT | |
| SCHEMBL14917442 | 0.60 | MAP2K3 (0.61) | MAP2K3MAPK14PARP1CDC7MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020061473-A1 | SMALL MOLECULES TARGETING MUTANT MAMMALIAN PROTEINS | JNANA THERAPEUTICS, INC. (US) | 2020-03-26 | — | — | WO | disclosed |