Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 3/20 | 0.65 |
| ▸ | MIF | P14174 | 5/20 | 0.62 |
| ▸ | MAOB | P27338 | 2/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.60 |
| ▸ | TNF | P01375 | 2/20 | 0.60 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | CES1 | P23141 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | STK17B | O94768 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Drinidene SCHEMBL2188660 | 1.00 | MAOA (0.65) | MAOAMIFMAOBKDM4EMEN1 | |
| Drinidene SCHEMBL121997 | 1.00 | MAOA (0.65) | MAOAMIFMAOBKDM4EMEN1 | |
| Drinidene SCHEMBL28279862 | 0.96 | CYP19A1 (0.61) | MAOAMIFMAOBKDM4EMEN1 | |
| SCHEMBL2319027 | 0.85 | MAOA (0.90) | MAOAMIFMAOBKDM4EMEN1 | |
| SCHEMBL10673520 | 0.83 | MAOA (0.50) | MAOAMIFMAOBKDM4EMEN1 | |
| Anthrone SCHEMBL28117197 | 0.81 | MAOA (0.90) | MAOAMIFMAOBKDM4EMEN1 | |
| Anthrone SCHEMBL29448801 | 0.80 | MAOA (1.00) | MAOAMIFMAOBKDM4EMEN1 | |
| Anthrone SCHEMBL1527782 | 0.80 | MAOA (1.00) | MAOAMIFMAOBKDM4EMEN1 | |
| Anthrone SCHEMBL29357010 | 0.80 | MAOA (1.00) | MAOAMIFMAOBKDM4EMEN1 | |
| Anthrone SCHEMBL18143 | 0.80 | MAOA (1.00) | MAOAMIFMAOBKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4064272-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-12-20 | — | — | US | claimed |
| US-9550788-B2 | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof | SANOFI (FR) | 2017-01-24 | — | — | US | disclosed |
| EP-2342178-B1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | SANOFI SA (FR) | 2016-09-28 | — | — | EP | disclosed |
| US-20140349986-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | SANOFI (FR) | 2014-11-27 | — | — | US | disclosed |
| US-8822449-B2 | Substituted aminoindanes and analogs thereof, and the pharmaceutical use thereof | SANOFI (FR) | 2014-09-02 | — | — | US | disclosed |
| US-20110201590-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | SANOFI-AVENTIS (FR) | 2011-08-18 | — | — | US | disclosed |
| EP-2342178-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | Sanofi-Aventis (FR) | 2011-07-13 | — | — | EP | disclosed |
| WO-2010025856-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | SANOFI-AVENTIS (FR) | 2010-03-11 | — | — | WO | disclosed |
| US-4164514-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1979-08-14 | — | — | US | disclosed |
| US-4164514-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1979-08-14 | — | — | US | disclosed |
| US-4164514-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1979-08-14 | — | — | US | disclosed |
| US-4117012-A | AMINES, QUATERNARY AMMONIUM COMPOUNDS, OLEFIN EPOXIDES, HYDROXYQUINOLINES, AMINE PHENOXIDES, GLYCIDYL HALIDES AND ETHERS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |
| US-4117012-A | AMINES, QUATERNARY AMMONIUM COMPOUNDS, OLEFIN EPOXIDES, HYDROXYQUINOLINES, AMINE PHENOXIDES, GLYCIDYL HALIDES AND ETHERS | PFIZER INC. (US) | 1978-09-26 | — | — | US | disclosed |
| US-4064272-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064272-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4064272-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-12-20 | — | — | US | disclosed |
| US-4022836-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-4022836-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-05-10 | — | — | US | disclosed |
| US-4022836-A | 2-Aminomethyleneindanone analgesic agents | PFIZER INC. (US) | 1977-05-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201590-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | CFTR, AADAT, PKD1 | MAOA 701/4885MIF 1043/4885MAOB 625/4885 |
| US-20140349986-A1 | SUBSTITUTED AMINOINDANES AND ANALOGS THEREOF, AND THE PHARMACEUTICAL USE THEREOF | CFTR, AADAT, FANCI | MAOA 760/4885MIF 837/4885MAOB 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.