SCHEMBL21886632

SCHEMBL21886632

CN(C)/C=N/c1ccc(O)c(OC2CCN(C)CC2(F)F)c1C#N

nearest known ligand 0.30

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.30
MAPT P10636 1/20 0.30
RAB9A P51151 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25987143 0.89 ERBB2 (0.34) ALDH1A1MAPTRAB9A
SCHEMBL21886693 0.89 ALDH1A1 (0.30) ALDH1A1MAPTRAB9A
SCHEMBL21886635 0.82 EGFR (0.35)
SCHEMBL21886629 0.81 HRH3 (0.32)
SCHEMBL21886673 0.81 HRH3 (0.32)
SCHEMBL22232287 0.76 EGFR (0.35) ALDH1A1
SCHEMBL21473392 0.76 EGFR (0.35) ALDH1A1
SCHEMBL22232285 0.76 EGFR (0.35) ALDH1A1
SCHEMBL21481104 0.74 TBK1 (0.36) MAPT
SCHEMBL21886653 0.74 ERBB2 (0.36) ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020057511-A1 QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS SUZHOU ZANRONG PHARMA LIMITED (CN) 2020-03-26 WO disclosed