Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.31 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25987143 | 0.87 | ERBB2 (0.34) | ERBB2TBK1CHEK1 | |
| SCHEMBL21886628 | 0.84 | ERBB2 (0.39) | EGFRERBB2IKBKETBK1CHEK1 | |
| SCHEMBL28564240 | 0.84 | EGFR (0.37) | EGFRERBB2IKBKETBK1CHEK1 | |
| SCHEMBL28555129 | 0.84 | ERBB2 (0.39) | EGFRERBB2IKBKETBK1CHEK1 | |
| SCHEMBL21886669 | 0.84 | EGFR (0.37) | EGFRERBB2IKBKETBK1CHEK1 | |
| SCHEMBL21886693 | 0.83 | ALDH1A1 (0.30) | — | |
| SCHEMBL21886632 | 0.82 | ALDH1A1 (0.30) | — | |
| SCHEMBL28569853 | 0.80 | PDE4D (0.36) | EGFRERBB2CHEK1 | |
| SCHEMBL28569856 | 0.80 | PDE4D (0.36) | EGFRERBB2CHEK1 | |
| SCHEMBL21886730 | 0.76 | CHEK1 (0.38) | EGFRERBB2CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230293533-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2023-09-21 | — | — | US | disclosed |
| US-20230293533-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2023-09-21 | — | — | US | disclosed |
| US-11723908-B2 | Quinazoline derivatives as antitumor agents | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2023-08-15 | — | — | US | disclosed |
| US-11723908-B2 | Quinazoline derivatives as antitumor agents | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2023-08-15 | — | — | US | disclosed |
| US-20210386742-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | HOFFMANN-LA ROCHE INC. | 2021-12-16 | — | — | US | disclosed |
| WO-2020057511-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | SUZHOU ZANRONG PHARMA LIMITED (CN) | 2020-03-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210386742-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ABL1, TP53, JAK1 | EGFR 117/4885ERBB2 29/4885IKBKE 133/4885 |
| US-11723908-B2 | Quinazoline derivatives as antitumor agents | ABL1, TP53, JAK1 | EGFR 117/4885ERBB2 29/4885IKBKE 133/4885 |
| US-20230293533-A1 | QUINAZOLINE DERIVATIVES AS ANTITUMOR AGENTS | ABL1, TP53, JAK1 | EGFR 117/4885ERBB2 29/4885IKBKE 133/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.