Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 9/20 | 0.53 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.37 |
| ▸ | RXRA | P19793 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887871 | 0.84 | NR1H2 (0.43) | NR1H2GRIA2KCNH2JAK2PIK3CD | |
| SCHEMBL21888599 | 0.84 | NR1H2 (0.44) | NR1H2GRIA2KCNH2JAK2PIK3CD | |
| SCHEMBL21887872 | 0.76 | NR1H2 (0.39) | NR1H2JAK2PIK3CDPIK3CGNR1H3 | |
| SCHEMBL21887738 | 0.74 | HTR2A (0.32) | — | |
| SCHEMBL16566072 | 0.70 | NR1H2 (1.00) | NR1H2GRIA2KCNH2JAK2PIK3CD | |
| SCHEMBL16553570 | 0.68 | NR1H2 (0.73) | NR1H2KCNH2PIK3CDPIK3CGNR1H3 | |
| SCHEMBL21888601 | 0.67 | NR1H2 (0.42) | NR1H2NR1H3RXRA | |
| SCHEMBL20879888 | 0.66 | NR1H2 (0.47) | NR1H2GRIA2KCNH2JAK2PIK3CD | |
| SCHEMBL6243674 | 0.65 | KCNH2 (0.50) | NR1H2KCNH2JAK2NR1H3 | |
| SCHEMBL16553577 | 0.64 | NR1H2 (0.67) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |