Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21888599 | 0.84 | NR1H2 (0.44) | NR1H2PIK3CDPIK3CGKCNH2JAK2 | |
| SCHEMBL21887872 | 0.84 | NR1H2 (0.39) | NR1H2PIK3CDPIK3CGJAK2DPP4 | |
| SCHEMBL21887739 | 0.84 | NR1H2 (0.53) | NR1H2PIK3CDPIK3CGKCNH2JAK2 | |
| SCHEMBL21887769 | 0.71 | NR1H2 (0.59) | NR1H2RXRANR1H3 | |
| SCHEMBL16553537 | 0.69 | NR1H2 (0.79) | NR1H2PIK3CDPIK3CGKCNH2RXRA | |
| SCHEMBL21887770 | 0.68 | NR1H2 (0.39) | NR1H2JAK2JAK3RXRANR1H3 | |
| SCHEMBL21888601 | 0.68 | NR1H2 (0.42) | NR1H2RXRANR1H3 | |
| SCHEMBL24572933 | 0.67 | CAMKK2 (0.50) | NR1H2CAMKK2KCNH2GRK6NR1H3 | |
| SCHEMBL2342732 | 0.65 | CAMKK2 (0.59) | CAMKK2RXRA | |
| SCHEMBL29374737 | 0.65 | CAMKK2 (0.59) | CAMKK2RXRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |