Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 6/20 | 0.39 |
| ▸ | IDH2 | P48735 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | CTSL | P07711 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.34 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.34 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21887770 | 0.85 | NR1H2 (0.39) | NR1H2RXRANR1H3JAK2JAK1 | |
| SCHEMBL21887871 | 0.84 | NR1H2 (0.43) | NR1H2PIK3CDPIK3CGRXRANR1H3 | |
| SCHEMBL21888599 | 0.79 | NR1H2 (0.44) | NR1H2PIK3CDPIK3CGRXRANR1H3 | |
| SCHEMBL21887739 | 0.76 | NR1H2 (0.53) | NR1H2PIK3CDPIK3CGRXRANR1H3 | |
| SCHEMBL3472767 | 0.76 | NR1H2 (0.45) | NR1H2IDH2CTSLCTSBCTSS | |
| SCHEMBL16553538 | 0.75 | NR1H2 (0.67) | NR1H2IDH2PIK3CDPIK3CGCTSL | |
| SCHEMBL3472382 | 0.71 | NR1H2 (0.46) | NR1H2IDH2CTSLCTSBCTSS | |
| SCHEMBL16126467 | 0.69 | NR1H2 (0.41) | NR1H2IDH2RXRANR1H3CHRNB2 | |
| SCHEMBL3473255 | 0.68 | NR1H2 (0.69) | NR1H2IDH2RXRANR1H3 | |
| SCHEMBL3470791 | 0.68 | RXRA (0.73) | NR1H2IDH2RXRANR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |