Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.47 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.36 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.36 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 4/20 | 0.34 |
| ▸ | PPARA | Q07869 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553546 | 0.85 | NR1H2 (0.67) | NR1H2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20845532 | 0.84 | NR1H2 (0.54) | NR1H2SMPD1MALT1 | |
| SCHEMBL25880815 | 0.78 | NR1H2 (0.55) | NR1H2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16553538 | 0.78 | NR1H2 (0.67) | NR1H2APLNR | |
| SCHEMBL21887746 | 0.77 | NR1H2 (0.45) | NR1H2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL20575099 | 0.68 | NR1H2 (0.37) | NR1H2 | |
| SCHEMBL16553554 | 0.68 | NR1H2 (0.77) | NR1H2 | |
| SCHEMBL25880809 | 0.67 | NR1H2 (0.41) | NR1H2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL29496569 | 0.65 | NR1H2 (0.73) | NR1H2 | |
| SCHEMBL16566131 | 0.65 | NR1H2 (0.73) | NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |