Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 4/20 | 0.45 |
| ▸ | APLNR | P35414 | 5/20 | 0.38 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.35 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16553538 | 0.83 | NR1H2 (0.67) | NR1H2APLNR | |
| SCHEMBL21887706 | 0.77 | NR1H2 (0.61) | NR1H2SLC16A3SLC16A1TRPV1 | |
| SCHEMBL21887741 | 0.77 | NR1H2 (0.47) | NR1H2APLNRCACNA1GCACNA1HMALT1 | |
| SCHEMBL16553546 | 0.76 | NR1H2 (0.67) | NR1H2MALT1SMPD1HDAC3HDAC4 | |
| SCHEMBL21887745 | 0.76 | NR1H2 (0.47) | NR1H2SLC16A3SLC16A1TRPV1 | |
| SCHEMBL17943746 | 0.68 | NR1H2 (0.58) | NR1H2SLC16A3SLC16A1TRPV1 | |
| SCHEMBL20430776 | 0.68 | CHRNB2 (0.34) | CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL21887703 | 0.67 | NR1H2 (0.40) | NR1H2 | |
| SCHEMBL20374835 | 0.66 | SYK (0.41) | NR1H2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL16566071 | 0.65 | NR1H2 (0.82) | NR1H2SLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3626712-A2 | LIVER X RECEPTOR (LXR) MODULATORS | Ellora Therapeutics, Inc. (US) | 2020-03-25 | — | — | EP | disclosed |