Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 10/20 | 0.33 |
| ▸ | LIPG | Q9Y5X9 | 10/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.32 |
| ▸ | F11 | P03951 | 1/20 | 0.30 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31500593 | 0.82 | LPL (0.38) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL565431 | 0.82 | GRM2 (0.39) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL565363 | 0.82 | GRM2 (0.39) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL565362 | 0.82 | GRM2 (0.39) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL565945 | 0.79 | LPL (0.33) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL565944 | 0.79 | LPL (0.33) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL566038 | 0.79 | LPL (0.33) | LPLLIPGIRAK4ROCK1 | |
| SCHEMBL7861274 | 0.78 | DGAT1 (0.38) | LPLLIPGIRAK4 | |
| SCHEMBL17136711 | 0.74 | HTR6 (0.36) | LPLLIPGIRAK4HIF1A | |
| SCHEMBL484221 | 0.72 | PRKCI (0.46) | LPLLIPGIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2346505-A1 | INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Ortho-McNeil-Janssen Pharmaceuticals, Inc. (US) | 2011-07-27 | — | — | EP | disclosed |
| WO-2010043396-A1 | INDOLE AND BENZOMORPHOLINE DERIVATIVES AS MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC. (US) | 2010-04-22 | — | — | WO | disclosed |