Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 5/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24375495 | 0.84 | IRAK4 (0.41) | LMNAIRAK4ATRPDE4DMTOR | |
| SCHEMBL24375533 | 0.80 | MTOR (0.44) | IRAK4ATRMTORPIK3CAPIK3CD | |
| SCHEMBL28003505 | 0.78 | ATR (0.46) | IRAK4ATRPDE4DMTORPIK3CA | |
| SCHEMBL13634271 | 0.78 | IRAK4 (0.39) | IRAK4ATRPDE4DMTORPIK3CA | |
| SCHEMBL18674649 | 0.76 | LMNA (1.00) | LMNAOGA | |
| SCHEMBL20594891 | 0.76 | IRAK4 (0.51) | IRAK4MTORPIK3CAPIK3C3OGA | |
| SCHEMBL10278349 | 0.76 | IRAK4 (0.51) | IRAK4MTORPIK3CAPIK3C3OGA | |
| SCHEMBL13162764 | 0.76 | MTOR (0.41) | IRAK4ATRPDE4DMTORPIK3C3 | |
| SCHEMBL20594858 | 0.73 | IRAK4 (0.51) | IRAK4MTORPIK3CA | |
| SCHEMBL30629327 | 0.71 | HRH4 (0.51) | ATRMTORPIK3CAPIK3CDPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | GENENTECH, INC. (US) | 2020-04-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200115388-A1 | IRAK4 MODULATORS | IRAK4, IRAK1, IRAK2 | LMNA 2525/4885IRAK4 1/4885ATR 993/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.