SCHEMBL21889536

SCHEMBL21889536

c1ccc(COc2ccc(-c3nc(CC4CCCC4)n[nH]3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 16/20 0.47
DHODH Q02127 1/20 0.43
PTGES O14684 1/20 0.43
ALOX5 P09917 1/20 0.43
LTC4S Q16873 1/20 0.43
IKBKE Q14164 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21914803 0.81 PRMT5 (0.52) PRMT5PTGESALOX5LTC4SIKBKE
SCHEMBL21914579 0.79 PRMT5 (0.52) PRMT5PTGESALOX5LTC4SIKBKE
SCHEMBL21889198 0.78 PRMT5 (0.57) PRMT5PTGESALOX5LTC4SIKBKE
SCHEMBL21889308 0.77 PRMT5 (0.47) PRMT5DHODHPTGESALOX5LTC4S
SCHEMBL21889009 0.76 AOC3 (0.70)
SCHEMBL23590409 0.72 PRMT5 (0.45) PRMT5DHODHPTGESALOX5LTC4S
SCHEMBL21914562 0.72 PRMT5 (0.49) PRMT5DHODHPTGESALOX5LTC4S
SCHEMBL25836249 0.72 IKBKE (0.50) PRMT5DHODHPTGESALOX5LTC4S
SCHEMBL21914810 0.71 PRMT5 (0.46) PRMT5DHODHPTGESALOX5LTC4S
SCHEMBL21914361 0.70 CHEK2 (0.56) PRMT5DHODHIKBKE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3626699-B1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2023-07-12 EP disclosed
US-20210198220-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-07-01 US disclosed
US-11001563-B2 SSAO inhibitor SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-11 US disclosed
US-20200115352-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-16 US disclosed
EP-3626699-A1 SSAO INHIBITOR Shandong Danhong Pharmaceutical Co., Ltd. (CN) 2020-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001563-B2 SSAO inhibitor SSB, ASAH2, AOX1 PRMT5 3044/4885DHODH 80/4885PTGES 582/4885
US-20210198220-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 PRMT5 3044/4885DHODH 80/4885PTGES 582/4885
US-20200115352-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 PRMT5 3044/4885DHODH 80/4885PTGES 582/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.