SCHEMBL21889537

SCHEMBL21889537

C[Si](C)(C)CCOCn1nc(CC2CCCC2)nc1-c1ccc(OCc2ccccc2)cc1

nearest known ligand 0.43

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 2/20 0.43
ALOX5 P09917 1/20 0.39
ENPP3 O14638 1/20 0.39
ENPP1 P22413 1/20 0.39
MERTK Q12866 1/20 0.38
MAOB P27338 2/20 0.38
FOXM1 Q08050 1/20 0.37
PTGES O14684 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37
SLC6A4 P31645 1/20 0.37
VCP P55072 1/20 0.36
FDFT1 P37268 1/20 0.36
WDR5 P61964 1/20 0.36
KDM4E B2RXH2 1/20 0.36
KMT2A Q03164 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
PRMT5 O14744 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21889821 0.85 DGAT1 (0.44) DGAT1ALOX5ENPP3ENPP1MERTK
SCHEMBL21889534 0.84 DGAT1 (0.35) DGAT1SMN1; SMN2
SCHEMBL21889298 0.83 DGAT1 (0.44) DGAT1ALOX5ENPP3ENPP1MERTK
SCHEMBL21889304 0.83 DGAT1 (0.45) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889199 0.83 DGAT1 (0.45) DGAT1ALOX5ENPP3ENPP1MERTK
SCHEMBL21889844 0.79 DGAT1 (0.44) DGAT1ALOX5ENPP3ENPP1MERTK
SCHEMBL21889554 0.78 DGAT1 (0.45) DGAT1ENPP3ENPP1MERTKMAOB
SCHEMBL16661083 0.78 DGAT1 (0.46) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889223 0.78 DGAT1 (0.46) DGAT1ENPP3ENPP1MAOBPTGES
SCHEMBL21889837 0.77 AOC3 (0.46) DGAT1ENPP3ENPP1MAOBPTGES

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3626699-B1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2023-07-12 EP disclosed
US-20210198220-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-07-01 US disclosed
US-11001563-B2 SSAO inhibitor SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-11 US disclosed
US-20200115352-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-16 US disclosed
EP-3626699-A1 SSAO INHIBITOR Shandong Danhong Pharmaceutical Co., Ltd. (CN) 2020-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001563-B2 SSAO inhibitor SSB, ASAH2, AOX1 DGAT1 3115/4885ALOX5 82/4885ENPP3 497/4885
US-20210198220-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885ALOX5 82/4885ENPP3 497/4885
US-20200115352-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885ALOX5 82/4885ENPP3 497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.