SCHEMBL21889841

SCHEMBL21889841

C[Si](C)(C)CCOCn1nc(C2COC2)nc1-c1ccc(O)cc1

nearest known ligand 0.34

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 6/20 0.34
MAOB P27338 3/20 0.32
MAOA P21397 2/20 0.32
ATR Q13535 1/20 0.32
ATRIP Q8WXE1 1/20 0.32
KLKB1 P03952 1/20 0.31
USP7 Q93009 1/20 0.31
AOC3 Q16853 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21889200 0.91 AOC3 (0.37) DGAT1MAOBMAOAKLKB1USP7
SCHEMBL21889523 0.89 DGAT1 (0.35) DGAT1MAOBMAOAATRATRIP
SCHEMBL21889297 0.89 DGAT1 (0.36) DGAT1MAOBMAOAKLKB1USP7
SCHEMBL21914802 0.89 DGAT1 (0.36) DGAT1MAOBMAOAKLKB1USP7
SCHEMBL21889844 0.84 DGAT1 (0.44) DGAT1MAOB
SCHEMBL21889556 0.82 DGAT1 (0.33) DGAT1MAOBMAOAKLKB1
SCHEMBL21889534 0.76 DGAT1 (0.35) DGAT1KLKB1USP7
SCHEMBL16661224 0.75 DGAT1 (0.42) DGAT1
SCHEMBL21914812 0.75 AOC3 (0.35) DGAT1AOC3
SCHEMBL21889839 0.75 AOC3 (0.45) DGAT1AOC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3626699-B1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2023-07-12 EP disclosed
US-20210198220-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-07-01 US disclosed
US-11001563-B2 SSAO inhibitor SHANDONG DANHONG PHARMACEUTICAL CO LTD (CN) 2021-05-11 US disclosed
US-20200115352-A1 SSAO INHIBITOR SHANDONG DANHONG PHARMACEUTICAL CO., LTD. 2020-04-16 US disclosed
EP-3626699-A1 SSAO INHIBITOR Shandong Danhong Pharmaceutical Co., Ltd. (CN) 2020-03-25 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11001563-B2 SSAO inhibitor SSB, ASAH2, AOX1 DGAT1 3115/4885MAOB 78/4885MAOA 74/4885
US-20210198220-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885MAOB 78/4885MAOA 74/4885
US-20200115352-A1 SSAO INHIBITOR SSB, ASAH2, AOX1 DGAT1 3115/4885MAOB 78/4885MAOA 74/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.