Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP8 | Q14790 | 5/20 | 0.56 |
| ▸ | FNTA | P49354 | 5/20 | 0.54 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.54 |
| ▸ | CASP3 | P42574 | 4/20 | 0.51 |
| ▸ | CASP7 | P55210 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187514 | 0.80 | SMN1; SMN2 (0.46) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL14842332 | 0.76 | CASP8 (0.74) | CASP8FNTAPGGT1BCASP3CASP7 | |
| SCHEMBL2187668 | 0.74 | KMT2A (0.48) | NPC1RAB9ASMN1; SMN2KDM4ETDP1 | |
| SCHEMBL2186525 | 0.73 | NFKB1 (0.45) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL3875594 | 0.73 | CASP8 (1.00) | CASP8FNTAPGGT1BCASP3CASP7 | |
| SCHEMBL2186570 | 0.73 | NFKB1 (0.43) | NPC1RAB9ASMN1; SMN2POLBTDP1 | |
| SCHEMBL6610226 | 0.72 | CASP8 (0.79) | CASP8FNTAPGGT1BCASP3CASP7 | |
| SCHEMBL2186970 | 0.71 | NPC1 (0.49) | CASP3NPC1RAB9ASMN1; SMN2KDM4E | |
| SCHEMBL2187048 | 0.71 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2KDM4EPKM | |
| SCHEMBL2186689 | 0.71 | NPC1 (0.52) | NPC1RAB9ASMN1; SMN2KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |