Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | CASR | P41180 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187574 | 0.85 | GAA (0.44) | KMT2AMEN1MAPK1L3MBTL1KDM4E | |
| SCHEMBL2187686 | 0.81 | SMN1; SMN2 (0.46) | KMT2AMEN1MAPK1L3MBTL1KDM4E | |
| SCHEMBL2187370 | 0.79 | SCD (0.48) | KMT2AMEN1GAASLC40A1NPC1 | |
| SCHEMBL2187394 | 0.75 | IRAK4 (0.49) | L3MBTL1 | |
| SCHEMBL2187514 | 0.75 | SMN1; SMN2 (0.46) | KDM4ESLC40A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL2189162 | 0.74 | CASP8 (0.56) | KDM4ENPC1RAB9ASMN1; SMN2TDP1 | |
| SCHEMBL2186970 | 0.73 | NPC1 (0.49) | KMT2AMEN1KDM4EGAASLC40A1 | |
| SCHEMBL2187048 | 0.73 | NPC1 (0.63) | KMT2AMEN1KDM4ENPC1RAB9A | |
| SCHEMBL2186689 | 0.73 | NPC1 (0.52) | KMT2AMEN1KDM4ENPC1RAB9A | |
| SCHEMBL16767096 | 0.72 | CSNK1E (0.53) | L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2343293-A1 | NOVEL PIPERIDIN-4-YL-THIAZOLE-CARBOXAMIDE ANALOGUES AS INHIBITORS OF T-CELL PROLIFERATION AND USES THEREOF | 4SC AG (DE) | 2011-07-13 | — | — | EP | disclosed |