SCHEMBL2189708

SCHEMBL2189708

O=C(c1ccccc1F)c1ccccc1Cl

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.57
ALOX15 P16050 1/20 0.57
TP53 P04637 1/20 0.56
CES2 O00748 2/20 0.56
CES1 P23141 2/20 0.56
RECQL P46063 1/20 0.53
POLB P06746 1/20 0.50
MAPK13 O15264 1/20 0.48
MAPK12 P53778 1/20 0.48
MAPK11 Q15759 1/20 0.48
MAPK14 Q16539 1/20 0.48
KMT2A Q03164 5/20 0.47
MEN1 O00255 3/20 0.47
GAA P10253 1/20 0.47
RORC P51449 1/20 0.46
RORB Q92753 1/20 0.46
MAPT P10636 2/20 0.46
TDP1 Q9NUW8 1/20 0.46
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29399311 0.87 CES2 (0.71) ALDH1A1CES2CES1RECQLPOLB
SCHEMBL250099 0.87 CES2 (0.71) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL50416 0.87 CES2 (0.71) ALDH1A1CES2CES1RECQLPOLB
SCHEMBL30293901 0.87 CES2 (0.71) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL3444846 0.84 CES2 (0.68) ALDH1A1CES2CES1RECQLPOLB
Hydrochloric Acid SCHEMBL27733532 0.84 CES2 (0.68) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL27185988 0.84 CES2 (0.68) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL31574193 0.84 CES2 (0.68) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL611462 0.84 MEN1 (0.54) ALDH1A1ALOX15CES2CES1KMT2A
SCHEMBL7544330 0.83 ALDH1A1 (0.48) ALDH1A1ALOX15TP53CES2CES1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9815937-B2 Process for preparing a poly(aryl ether ketone) using a high purity 4,4′-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-11-14 US claimed
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US claimed
EP-2342259-B1 IMPROVED PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'-DIFLUOROBENZOPHENONE SOLVAY SPECIALTY POLYMERS USA (US) 2013-08-07 EP claimed
US-20110213115-A1 Process for preparing a poly(aryl ether ketone) using a high purity 4,4'-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2011-09-01 US claimed
EP-2342259-A1 IMPROVED PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'-DIFLUOROBENZOPHENONE Solvay Advanced Polymers, L.L.C. (US) 2011-07-13 EP claimed
WO-2010046483-A1 IMPROVED PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'-DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2010-04-29 WO claimed
US-9815937-B2 Process for preparing a poly(aryl ether ketone) using a high purity 4,4′-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-11-14 US disclosed
US-9815937-B2 Process for preparing a poly(aryl ether ketone) using a high purity 4,4′-difluorobenzophenone SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2017-11-14 US disclosed
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US disclosed
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE SOLVAY ADVANCED POLYMERS, L.L.C. (US) 2016-05-26 US disclosed
CN-102197064-B Improved process for preparing poly (aryl ether ketones) using high purity 4, 4' -difluorobenzophenone SOLVAY ADVANCED POLYMERS LLC 2014-08-13 CN disclosed
EP-2342259-B1 IMPROVED PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'-DIFLUOROBENZOPHENONE SOLVAY SPECIALTY POLYMERS USA (US) 2013-08-07 EP disclosed
CN-102197064-A Improved process for preparing poly (aryl ether ketones) using high purity 4, 4' -difluorobenzophenone SOLVAY ADVANCED POLYMERS LLC 2011-09-21 CN disclosed
US-20080118853-A1 BRANCHED POLYARYLENE ETHERS AND PROCESSES FOR THE PREPARATION THEREOF XEROX CORPORATION (US) 2008-05-22 US disclosed
US-7067608-B2 Process for preparing branched polyarylene ethers XEROX CORPORATION (US) 2006-06-27 US disclosed
US-20050208416-A1 Branched polyarylene ethers and processes for the preparation thereof XEROX CORPORATION 2005-09-22 US disclosed
US-6927273-B2 Microelectronics applications; heat stable, electrically insulating, and mechanically robust photopatternable materials; low shrinkage during post-cure steps XEROX CORPORATION (US) 2005-08-09 US disclosed
US-20050154178-A1 Process for preparing branched polyarylene ethers XEROX CORPORATION 2005-07-14 US disclosed
US-20040122204-A1 Process for preparing substituted polyarylene ethers XEROX CORPORATION. 2004-06-24 US disclosed
EP-0202082-B1 AROMATIC POLYETHERKETONE FIBER PRODUCT AND PROCESS CELANESE CORPORATION (US) 1992-09-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160145386-A1 PROCESS FOR PREPARING A POLY(ARYL ETHER KETONE) USING A HIGH PURITY 4,4'- DIFLUOROBENZOPHENONE HNF4A, CUL4B, CUL4A ALDH1A1 1653/4885ALOX15 4228/4885TP53 3499/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.