Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.47 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TOP2A | P11388 | 1/20 | 0.44 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.42 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.42 |
| ▸ | LIPE | Q05469 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16067437 | 0.85 | KMT2A (0.48) | ITGB1ITGA4ITGB7MAPTALDH1A1 | |
| SCHEMBL16067495 | 0.83 | ITGB1 (0.47) | ITGB1ITGA4ITGB7MAPTALDH1A1 | |
| SCHEMBL24454656 | 0.80 | ITGB1 (0.45) | ITGB1ITGA4ITGB7MAPTALDH1A1 | |
| SCHEMBL2059183 | 0.79 | ITGB3 (0.70) | ITGB1ITGA4ITGB7ITGB3ITGA2B | |
| SCHEMBL2059100 | 0.76 | P2RX7 (0.59) | ITGB1ITGA4ITGB7ITGB3ITGA2B | |
| SCHEMBL12863749 | 0.76 | TOP2A (0.52) | MAPTALDH1A1POLBTOP2ATOP2B | |
| SCHEMBL21689926 | 0.75 | ITGB1 (0.66) | ITGB1ITGA4ITGB7MAPTITGB3 | |
| SCHEMBL15134826 | 0.74 | CYP1A2 (0.69) | MAPTALDH1A1POLBCYP1A2CYP2C9 | |
| SCHEMBL10053020 | 0.74 | MAPT (0.60) | MAPTALDH1A1POLBCYP1A2CYP2C9 | |
| SCHEMBL1735264 | 0.73 | ALDH1A1 (0.56) | MAPTALDH1A1POLBCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3938372-B1 | AZETIDOBENZODIAZEPINE DIMERS AND CONJUGATES COMPRISING THEM FOR USE IN THE TREATMENT OF CANCER | MEDIMMUNE LTD (GB) | 2023-10-25 | — | — | EP | disclosed |
| WO-2020079229-A1 | PYRROLOBENZODIAZEPINE CONJUGATES | MEDIMMUNE LIMITED (GB) | 2020-04-23 | — | — | WO | disclosed |