Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.32 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.32 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | NQO2 | P16083 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | IDH1 | O75874 | 1/20 | 0.30 |
| ▸ | ABL1 | P00519 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20542084 | 0.83 | CYP11B2 (0.36) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL21855471 | 0.81 | AHR (0.35) | AHRCYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL21754340 | 0.81 | CDK2 (0.35) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL20557664 | 0.80 | AHR (0.33) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL20541825 | 0.80 | AHR (0.49) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL20557924 | 0.80 | CYP11B2 (0.34) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL29619215 | 0.80 | AHR (0.49) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL22566871 | 0.78 | CYP11B2 (0.34) | AHRTLR7CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL24408393 | 0.76 | AHR (0.40) | AHRTLR7CYP11B2CYP11B1IDH1 | |
| SCHEMBL21855494 | 0.76 | HRH4 (0.39) | AHRTLR7CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081636-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | Ikena Oncology, Inc. (US) | 2020-04-23 | — | — | WO | disclosed |