Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 8/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 7/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.32 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.32 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.32 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 7/20 | 0.31 |
| ▸ | CDK7 | P50613 | 1/20 | 0.31 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20541825 | 1.00 | AHR (0.49) | AHRIDH1CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL24408393 | 0.88 | AHR (0.40) | AHRIDH1CYP11B2CYP11B1CHRNB2 | |
| SCHEMBL20558149 | 0.85 | AHR (0.49) | AHRCYP11B2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL21754321 | 0.85 | AHR (0.49) | AHRCYP11B2CYP11B1CHRNB2CHRNB4 | |
| SCHEMBL21855471 | 0.83 | AHR (0.35) | AHRCYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL20542084 | 0.83 | CYP11B2 (0.36) | AHRCYP11B2CYP11B1CYP17A1CHRNB2 | |
| SCHEMBL23771447 | 0.83 | AHR (0.56) | AHRIDH1CYP11B2CYP11B1TLR7 | |
| SCHEMBL21754340 | 0.81 | CDK2 (0.35) | AHRCYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL20557973 | 0.80 | AHR (0.41) | AHRCYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL20557924 | 0.80 | CYP11B2 (0.34) | AHRIDH1CYP11B2CYP11B1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110831600-B | Indole AHR inhibitors and uses thereof | 医肯纳肿瘤学公司 | 2023-10-17 | — | — | CN | disclosed |
| US-20220144839-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2022-05-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220144839-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | AHR 1/4885IDH1 1026/4885CYP11B2 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.