Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.34 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.32 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.31 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21855471 | 0.84 | AHR (0.35) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL20542084 | 0.84 | CYP11B2 (0.36) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL20557664 | 0.81 | AHR (0.33) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL21899482 | 0.81 | AHR (0.35) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL20557924 | 0.81 | CYP11B2 (0.34) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL24966052 | 0.81 | AHR (0.41) | CDK2CHEK1CCNA2CCNA1CYP11B2 | |
| SCHEMBL22566871 | 0.81 | CYP11B2 (0.34) | CYP11B2CYP11B1CYP17A1CYP3A4AHR | |
| SCHEMBL20541825 | 0.81 | AHR (0.49) | CDK2CYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL29619215 | 0.81 | AHR (0.49) | CDK2CYP11B2CYP11B1CYP17A1CYP3A4 | |
| SCHEMBL21855500 | 0.79 | POLB (0.33) | CYP11B2CYP11B1CYP17A1CYP3A4AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | PAHR THERAPEUTICS, INC. | 2023-01-26 | — | — | US | disclosed |
| US-10689388-B1 | Indole AHR inhibitors and uses thereof | Ikena Oncology, Inc. (US) | 2020-06-23 | — | — | US | disclosed |
| US-10570138-B2 | Indole AHR inhibitors and uses thereof | KYN THERAPEUTICS (US) | 2020-02-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10570138-B2 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | CDK2 1444/4885CHEK1 3921/4885CCNA2 3306/4885 |
| US-10689388-B1 | Indole AHR inhibitors and uses thereof | AHR, ARNT, IDO1 | CDK2 1444/4885CHEK1 3921/4885CCNA2 3306/4885 |
| US-20230028336-A1 | INDOLE AHR INHIBITORS AND USES THEREOF | AHR, ARNT, IDO1 | CDK2 1444/4885CHEK1 3921/4885CCNA2 3306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.