Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21901147 | 0.86 | MEN1 (0.30) | — | |
| SCHEMBL29535923 | 0.71 | GRM4 (0.39) | GAAGFERLMNATDO2GRM4 | |
| SCHEMBL21901151 | 0.71 | GRM4 (0.39) | GAAGFERLMNATDO2GRM4 | |
| SCHEMBL21901192 | 0.71 | GRM4 (0.43) | GAAGFERLMNATDO2GRM4 | |
| SCHEMBL21901257 | 0.71 | GRM4 (0.39) | GAAGFERLMNATDO2GRM4 | |
| SCHEMBL21901867 | 0.71 | GRM4 (0.43) | GAAGFERLMNATDO2GRM4 | |
| SCHEMBL21901148 | 0.70 | — | — | |
| SCHEMBL23199536 | 0.68 | PGK1 (0.30) | — | |
| SCHEMBL23883875 | 0.68 | ALDH1A1 (0.36) | GAAGFERLMNAGRM4 | |
| SCHEMBL26321089 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020081257-A1 | MODULATORS OF ALPHA-1 ANTITRYPSIN | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2020-04-23 | — | — | WO | disclosed |