Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A19 | Q695T7 | 1/20 | 0.51 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 3/20 | 0.45 |
| ▸ | MAOA | P21397 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10696920 | 0.92 | SLC6A19 (0.49) | SLC6A19HSD17B3CYP4F2CYP4A11BACE1 | |
| SCHEMBL21791369 | 0.82 | HSD17B3 (0.56) | SLC6A19HSD17B3BACE1PKMMAOB | |
| SCHEMBL19599777 | 0.82 | HPGD (0.50) | CYP4F2CYP4A11AKT1MAOBMAOA | |
| SCHEMBL571591 | 0.82 | HSD17B3 (0.56) | SLC6A19HSD17B3BACE1PKMMAOB | |
| SCHEMBL571592 | 0.82 | HSD17B3 (0.56) | SLC6A19HSD17B3BACE1PKMMAOB | |
| SCHEMBL19452350 | 0.82 | AKT1 (0.62) | CYP4F2CYP4A11AKT1MAOBMEN1 | |
| SCHEMBL7571411 | 0.82 | AKT1 (0.62) | CYP4F2CYP4A11AKT1MAOBMEN1 | |
| SCHEMBL10698275 | 0.80 | P4HB (0.51) | CYP4F2CYP4A11AKT1MAOBMAOA | |
| SCHEMBL10698280 | 0.80 | P4HB (0.51) | CYP4F2CYP4A11AKT1MAOBMAOA | |
| SCHEMBL10699103 | 0.79 | SLC6A19 (0.47) | SLC6A19HSD17B3CYP4F2CYP4A11BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2704571-B1 | AMINO-PYRIDINE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2020-04-22 | — | — | EP | disclosed |