Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.41 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.33 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.33 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21902910 | 0.86 | GABRA1 (0.44) | GABRA1GABRB2DPP4ALDH1A1MAPT | |
| SCHEMBL12413798 | 0.86 | GABRA1 (0.41) | GABRA1GABRB2RORCDPP4SIGMAR1 | |
| SCHEMBL11809009 | 0.85 | GABRA1 (0.55) | GABRA1GABRB2RORCDPP4ESR1 | |
| SCHEMBL24233039 | 0.81 | GABRA1 (0.43) | GABRA1GABRB2RORCDPP4ALDH1A1 | |
| SCHEMBL12436729 | 0.81 | ALDH1A1 (0.45) | DPP4ALDH1A1MAPTHTTL3MBTL1 | |
| SCHEMBL9389779 | 0.80 | BCHE (0.47) | GABRA1GABRB2RORCS1PR1 | |
| SCHEMBL9389759 | 0.80 | GABRA1 (0.46) | GABRA1GABRB2RORCDPP4ESR1 | |
| SCHEMBL9390909 | 0.79 | BCHE (0.49) | GABRA1GABRB2S1PR1 | |
| SCHEMBL2741641 | 0.76 | KDM4E (0.42) | GABRA1GABRB2ESR1ALDH1A1MAPT | |
| SCHEMBL12413796 | 0.75 | GABRA1 (0.44) | GABRA1GABRB2RORCMAPTS1PR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020078933-A1 | PROTEOLYSIS TARGETING CHIMERA (PROTACS) AS DEGRADERS OF SMARCA2 AND/OR SMARCA4 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |