Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17347665 | 0.85 | MEN1 (0.36) | NPC1RAB9A | |
| SCHEMBL19532862 | 0.81 | NPC1 (0.34) | CRBNNPC1RAB9A | |
| SCHEMBL20786103 | 0.80 | NPC1 (0.35) | CRBNNPC1RAB9A | |
| SCHEMBL29388571 | 0.80 | NPC1 (0.40) | CRBNNPC1RAB9A | |
| SCHEMBL29471925 | 0.80 | NPC1 (0.40) | CRBNNPC1RAB9A | |
| SCHEMBL2248688 | 0.80 | NPC1 (0.40) | CRBNNPC1RAB9A | |
| SCHEMBL2250757 | 0.79 | ALDH1A1 (0.40) | NPC1RAB9A | |
| SCHEMBL19603297 | 0.79 | ALDH1A1 (0.40) | NPC1RAB9A | |
| SCHEMBL29790770 | 0.79 | ALDH1A1 (0.40) | NPC1RAB9A | |
| Formic Acid SCHEMBL19630437 | 0.78 | NPC1 (0.37) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | NPSR1 2872/4885CRBN 5/4885NPC1 2550/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.