Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | TNKS | O95271 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2190722 | 1.00 | MEN1 (0.64) | MEN1KMT2AHDAC3TNKSHDAC4 | |
| SCHEMBL13435492 | 0.88 | MEN1 (0.57) | MEN1KMT2ABCHEACHENR1H4 | |
| SCHEMBL13912776 | 0.87 | MEN1 (0.65) | MEN1KMT2AHDAC1HDAC6BCHE | |
| SCHEMBL13435489 | 0.83 | MEN1 (0.70) | MEN1KMT2ABCHE | |
| SCHEMBL2191761 | 0.77 | MEN1 (0.61) | MEN1KMT2ABCHEKDM4E | |
| SCHEMBL2191763 | 0.77 | MEN1 (0.61) | MEN1KMT2ABCHEKDM4E | |
| SCHEMBL13461850 | 0.76 | MEN1 (0.55) | MEN1KMT2AHDAC1HDAC6BCHE | |
| SCHEMBL13912778 | 0.73 | MEN1 (0.54) | MEN1KMT2AHDAC1HDAC6BCHE | |
| SCHEMBL20010460 | 0.72 | THRB (0.57) | HDAC3TNKSHDAC4HDAC1HCAR2 | |
| SCHEMBL10580674 | 0.72 | THRB (0.57) | HDAC3TNKSHDAC4HDAC1HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1509489-B1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2011-07-13 | — | — | EP | disclosed |
| EP-1509489-B1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC (US) | 2011-07-13 | — | — | EP | disclosed |
| US-7671087-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671087-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-7671087-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR INC. (US) | 2010-03-02 | — | — | US | disclosed |
| US-20090163593-A1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | AQUILA BRIAN M | 2009-06-25 | — | — | US | disclosed |
| US-20090163593-A1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | AQUILA BRIAN M | 2009-06-25 | — | — | US | disclosed |
| US-20090163593-A1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | AQUILA BRIAN M | 2009-06-25 | — | — | US | disclosed |
| US-7511073-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511073-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-7511073-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR, INC. (US) | 2009-03-31 | — | — | US | disclosed |
| US-20060281742-A1 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | AQUILA BRIAN M | 2006-12-14 | — | — | US | disclosed |
| US-7049329-B2 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR INC. (US) | 2006-05-23 | — | — | US | disclosed |
| US-20040048907-A1 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SEPRACOR INC. | 2004-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040048907-A1 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SLC6A2, HTR2A, SLC18A1 | MEN1 917/4885KMT2A 771/4885HDAC3 2289/4885 |
| US-20060281742-A1 | Amines that inhibit a mammalian anandamide transporter, and methods of use thereof | SLC6A2, HTR2A, SLC18A1 | MEN1 917/4885KMT2A 771/4885HDAC3 2289/4885 |
| US-20090163593-A1 | AMINES THAT INHIBIT A MAMMALIAN ANANDAMIDE TRANSPORTER, AND METHODS OF USE THEREOF | SLC6A2, HTR2A, SLC18A1 | MEN1 917/4885KMT2A 771/4885HDAC3 2289/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.