Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 2/20 | 0.37 |
| ▸ | NOS3 | P29474 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 2/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | GLS | O94925 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21907282 | 0.80 | TACR1 (0.34) | KMT2AKDM4EMEN1HTTATM | |
| SCHEMBL12585927 | 0.79 | NOS3 (0.38) | NOS3HSP90AA1HSP90AB1CTSKCTSS | |
| SCHEMBL18352285 | 0.78 | HSP90AA1 (0.40) | NOS1NOS3HSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL6794970 | 0.78 | HSP90AA1 (0.36) | KMT2ATACR1HSP90AA1HSP90AB1 | |
| Hydrochloric Acid SCHEMBL29351155 | 0.76 | HSP90AA1 (0.39) | NOS1NOS3HSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL10025587 | 0.76 | HSP90AA1 (0.46) | HTTHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL18560881 | 0.75 | HSP90AA1 (0.38) | KMT2AKDM4EMEN1HTTATM | |
| SCHEMBL18357827 | 0.74 | CACNA1B (0.54) | KDM4ETACR1 | |
| SCHEMBL12874041 | 0.72 | CACNA1H (0.43) | NOS1NOS3HSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL17396787 | 0.72 | KDM4E (0.48) | KMT2AKDM4EMEN1GLS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3316887-B1 | GLS1 INHIBITORS FOR TREATING DISEASE | UNIV TEXAS (US) | 2020-04-08 | — | — | EP | disclosed |