Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 1/20 | 0.34 |
| ▸ | POLQ | O75417 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | PHGDH | O43175 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | FBP1 | P09467 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | GLS | O94925 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19534277 | 0.81 | TACR1 (0.36) | TACR1SMN1; SMN2KDM4E | |
| SCHEMBL21907306 | 0.80 | NOS1 (0.37) | TACR1KMT2AHTTKDM4EMEN1 | |
| SCHEMBL18132199 | 0.77 | GAA (0.40) | KMT2AGAASMN1; SMN2KDM4EMEN1 | |
| SCHEMBL12585927 | 0.74 | NOS3 (0.38) | POLQPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6794970 | 0.73 | HSP90AA1 (0.36) | TACR1POLQKMT2AGAASORT1 | |
| SCHEMBL18352285 | 0.73 | HSP90AA1 (0.40) | POLQHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL18357827 | 0.72 | CACNA1B (0.54) | TACR1KDM4EFBP1 | |
| Hydrochloric Acid SCHEMBL29351155 | 0.71 | HSP90AA1 (0.39) | POLQHSD17B10HSP90AA1HSP90AB1 | |
| SCHEMBL10025587 | 0.71 | HSP90AA1 (0.46) | GAAHTTSMN1; SMN2SORT1HSD17B10 | |
| SCHEMBL17396787 | 0.71 | KDM4E (0.48) | POLQKMT2AGAAKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3316887-B1 | GLS1 INHIBITORS FOR TREATING DISEASE | UNIV TEXAS (US) | 2020-04-08 | — | — | EP | disclosed |