Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 5/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.34 |
| ▸ | PTGER2 | P43116 | 2/20 | 0.34 |
| ▸ | GHSR | Q92847 | 2/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21906532 | 0.88 | RXRB (0.45) | RXRB | |
| SCHEMBL21907351 | 0.82 | MEN1 (0.47) | RXRBL3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL21907354 | 0.81 | RXRB (0.47) | RXRBKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21906515 | 0.81 | RXRB (0.50) | RXRBKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21906702 | 0.79 | HTT (0.42) | RXRBL3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL21906696 | 0.77 | HTT (0.47) | RXRBSLC6A2SLC6A4SLC6A3L3MBTL1 | |
| SCHEMBL21906498 | 0.74 | L3MBTL1 (0.44) | RXRBL3MBTL1MEN1KMT2ACYP1A2 | |
| SCHEMBL21906688 | 0.69 | RXRB (0.47) | RXRBKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL23380132 | 0.68 | L3MBTL1 (0.44) | RXRBKCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL21902703 | 0.68 | ALDH1A1 (0.54) | RXRBKCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3867244-B1 | 4-PYRAZIN-2-YLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INT (DE) | 2023-01-18 | — | — | EP | disclosed |
| WO-2020079039-A1 | 4-PYRAZIN-2-YLMETHYL-MORPHOLINE DERIVATIVES AND THE USE THEREOF AS MEDICAMENT | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2020-04-23 | — | — | WO | disclosed |