Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20231219 | 0.94 | ALDH1A1 (0.45) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL21673581 | 0.91 | ALDH1A1 (0.46) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL20231220 | 0.90 | KDM4E (0.45) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL20234243 | 0.90 | ALDH1A1 (0.45) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL20234240 | 0.90 | HRH3 (0.41) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL27370590 | 0.90 | ALDH1A1 (0.44) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL20234239 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL22778298 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL21025901 | 0.90 | ALDH1A1 (0.47) | ALDH1A1KDM4EHRH3RAB9ADRD3 | |
| SCHEMBL13559781 | 0.90 | ALDH1A1 (0.51) | ALDH1A1KDM4EHRH3RAB9ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2023-07-25 | — | — | US | disclosed |
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2020-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10604506-B2 | Modulators of estrogen receptor proteolysis and associated methods of use | ADRM1, MDM2, ESR2 | ALDH1A1 2935/4885KDM4E 1787/4885HRH3 3598/4885 |
| US-11707452-B2 | Modulators of alpha-synuclein proteolysis and associated methods of use | UCHL1, ADRM1, CRBN | ALDH1A1 2567/4885KDM4E 2704/4885HRH3 3523/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.